DDI probability: 0.90 (probability of the predicted DDI type; interaction probability 1.00)



Submitted molecules:

Molecule 1: Nirmatrelvir

Molecule 2: Ritonavir

DDI type prediction:

The metabolism of Nirmatrelvir can be decreased when combined with Ritonavir.

Similarities:


MeTDDI Model interpretation for drug-drug interactions.

MeTDDI analysis consistent with DDI-GCN

Metabolic direction:
Nirmatrelvir metabolism decreased
MeTDDI class probabilities:
[0.6207, 0.3716, 0.0061, 0.0016]
victim attribution

Nirmatrelvir (victim) motifs

perpetrator attribution

Ritonavir (perpetrator) motifs

Mechanism evidence — VC / IG attribution of the perpetrator

Perpetrator: Ritonavir  |  CYP isoform: CYP3A4

perpetrator IG attribution

Ritonavir atom-level IG heatmap
(deeper green = atoms more responsible for the interaction)

Top contributing substructure

CN

Top-1 motif id: 11901

consensus across known victims

The full CYP mechanism reference is available in the Mechanism database.



Literature evidence